Recurrent In Vitro Fertilization Failures | Dr. Hakan Özörnek

Recurrent In Vitro Fertilization Failures

In the context of in vitro fertilization (IVF) failures, the importance of the uterus is as significant as the embryo. Recent developments, especially in recent years, have highlighted the crucial role of the uterus in the success of IVF treatments. The significance of the uterus poses challenges in three different aspects, particularly during IVF treatments.

One of these aspects is infections within the uterus. The unique characteristic of these infections is the absence of any apparent symptoms. They neither cause fever, nor pain, nor discharge. However, they hinder the implantation of the embryo. The treatment is relatively simple: an antibiotic therapy. We are aware that approximately 60% of our patients have such infections.

The second crucial aspect is the contractility of the uterus as a muscular organ. Even if there is minimal contraction at the millimeter level during embryo transfer, it pushes the embryo outward. Despite conducting an excellent transfer and providing a high-quality embryo, unfortunately, pregnancy does not occur. We find ourselves puzzled, wondering why pregnancy did not occur. Against this contraction, there is a significant medication treatment, which we apply to patients who have experienced 2-3 failures in previous treatments on the day of the transfer.

The third and highly significant point is the immune system. Unlike the overall immune system in the body, there is a different immune system within the uterus. Foreign entities entering the body, such as bacteria, viruses, or someone else's organ, are programmed to be expelled from the body. The immune system recognizes this and tries to remove it from the body. There is one exception to this; pregnancy. Despite half of the pregnancy being from the father, it is accepted by the mother's side. In other words, that pregnancy is tolerated within the uterus. When there is a disruption in this system, we encounter recurrent failures in IVF. Patients who have tried 3-4 times and experienced failure need to balance this immune system. For this, we use a serum that balances the immune system, ensuring that in the next treatment, the patient accepts this pregnancy and the IVF treatment is successful.

Therefore, while examining the embryo, considering factors such as being a 5-day blastocyst embryo or undergoing genetic analysis is crucial, it is not sufficient on its own. The condition of the uterus should not be overlooked. If there is a problem in the uterus, no matter how high-quality embryos you produce, the IVF treatment will not be successful.

Preventing this with accurate diagnosis and treatment is now possible. The solution is with us! Contact us via WhatsApp at 0541 324 58 85  to schedule your appointment without delay.


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