Tests to be Conducted for Couples with Recurrent IVF Failures

What is recurrent IVF failure?

Despite various definitions in the literature, the most widely accepted description of recurrent IVF failure is the inability of a couple to achieve pregnancy after three IVF treatments or a total of four embryo transfers despite the transfer of high-quality embryos.

What are the causes of recurrent IVF failures?

The causes can be embryo-related, uterus-related, or immune system-related.

Which tests should be performed for couples with recurrent IVF failures?

For couples experiencing recurrent IVF failures, we recommend karyotype analysis and hysteroscopy to assess the uterine cavity.

In cases where chromosomal abnormalities are detected in karyotype analysis, the genetic screening of embryos is performed. By transferring embryos with a healthy chromosomal structure, the chances of pregnancy are increased.

Hysteroscopy is used to address structural abnormalities, occupying lesions, or adhesions within the uterine cavity. If there are no issues in the uterus, the effectiveness of interventions such as "scratching the uterus" is not proven.

Testing for antiphospholipid antibodies in clotting tests can be performed, and there is no need to check for commonly encountered MTHFR mutations.

It is noteworthy that the number of couples for whom we do not identify any problems in tests conducted after three attempts of IVF is quite significant. Therefore, although obtaining a negative result can be financially and psychologically taxing for the patient, individuals should be patient and not pressure their doctors for expensive tests. In fact, personalized recommendations focusing on the quality of life (such as weight loss in overweight patients, quitting smoking, treating metabolic issues like diabetes and thyroid problems) are more effective than costly and unbeneficial tests.

If there is fluid in the fallopian tubes, tube surgery, removal of lesions such as polyps or fibroids increases the chances of success in subsequent treatments.

The quality and experience of the laboratory are also crucial. Collaborative evaluation of patients by the embryology laboratory and the clinician, if possible, providing what is known as a blastocyst, the 5th-day embryo, can be effective.

For patients believed to have issues with immune response, a serum treatment that addresses this problem can be applied.

Come to our center; let's conduct your IVF treatment. Let's start working together for you, prospective parents experiencing unsuccessful IVF attempts, to have children. Let's investigate and find solutions for the reasons behind IVF treatment failures. Let's be with you throughout the entire treatment process, from embryo development to selecting high-quality embryos, and apply the most suitable treatment for you.

For appointments, you can contact us via WhatsApp at 0541 324 58 85 or fill out the Appointment Request Form on our website.